No it wont work, but you can use filters and exclude all files you do not want to upload e.g.: create filelist.txt
with content:
path/to/file1
path/to/file2
path/to/fileX
and later add to sync --exclude-from filelist.txt
to create such list you can run at least on Linux:
rclone lsf --files-only -R src:| sort > src
rclone lsf --files-only -R dst:| sort > dst
comm -23 src dst > filelist.txt
You have to find your way to do this on Windows - but it should give you an idea how to proceed.