There are cons to the VFS layer. I had a few just yesterday. A large transfer of 80GB through radarr failed so it ended up having to redo it (which took 2 hours per try). I also notice a much slower speed through writing since it’s only using read chunk sizes not write chunk sizes, so it can’t upload multiple chunks at once I guess. Changing the buffer size doesn’t do anything either. This is the config I’m using though for VFS https://forum.rclone.org/t/new-feature-vfs-read-chunk-size/5683/84
An upside to using VFS though is a faster startup time for streaming files, no waiting for 40 seconds for the cache to build up since there isn’t one. And also too with these options, no doubling of needed HDD space for the rclone tmp upload folder since it uploads directly now (although that means no retries in rclone)