Sure.
cron is a little picky at times as you don’t usually get all your environment variables so it might require a little trial and error.
For a simple example, I use a script like this to clean up my trash every night on my Google Drive. I have to put my environment variable for where my rclone is in the script.
felix@gemini:~$ cat /home/felix/scripts/rclone_cleanup
#!/bin/bash
# RClone Config file
RCLONE_CONFIG=/data/rclone/rclone.conf
export RCLONE_CONFIG
/usr/bin/rclone cleanup GD: