I dont think there will be. The difference really is that when you're copying to the mount, its immediately transferring and so you'll need to wait for that to complete. It also won't have retries in the same way so if the transfer fails you'll need to reupload.
you don't need it for plex. That is a few year old problem. You may not even need vfs-cache-mode writes but that just depends on if/how your'e writing to it.